My own experience was that, except in the early game, creations were just a burden (keeping them alive became tedious). I absorbed them and I ended up putting most points into strength and endurance to get a tank. I do think melee is most powerful, with lots of quick action.
I think though it depends on the difficulty level. On normal, with enough endurance and the best armor you can ignore the attacks of all non-scripted enemies. Not so much on torment I think.
Otherwise items are key. Things become easier once you get assassin boots as you get 2 turns quite often. Firesteel gauntless give you the ability to cast acid rain which is the most useful attack spell. Corrupted batons are also excellent. Buy, steal or craft as many rods of succour, alacrity as you can.