have you tried anti virus? there are FREE online scans from symantec(www.symantec.com), mcafee, (www.mcafee.com), and a faster but not as through one called HouseCall, deveoped by TrendMicro whom made PC-cillin.
try spybot again. id put my heart to spybot s&d. if nothing works, backup all your data(dont forget gamesave files) and reinstall windows. you'll probably need new keys for ur spiderweb games.