In Escape from the pit, I tried various missions to start...completing what i could and planning to comeback to others once i'm stronger...only to find out that any mission i started and where i opened a secret door...now has said door seemingly permanently closed...in some cases making the mission impossible to complete!!!
Example: "Nepharim Prisoners" quest
An early quest given by Mayor Steele in Cotra...where you need to sneak in the Neparim Underground Fort through a secret passage to release the 10 prisoners...
My party was still too weak to complete the mission...