HighTyrol

I have read through earanhart's rules for geneforge in D&D and I am planning on running a one shot with it to test how it plays. I am fairly familiar with DnD but most of my GM experience is either from Pathfinder or forum based roleplays. Does anyone have any advice on how to build a dungeon/Scenario that will work well with this system? I was planning on having either 3 or 4 players plus creations.