My first guess (and only, for that matter) would be a background process and GF4 not getting along too well. Close out any background processes you aren't using and then try running it. If that doesn't fix it, you're not missing out on much.
If I remember correctly this error is the result of corrupt ram, not enough ram, or both. I used to get it in Garry's Mod but I saw the end of it after buying another stick of ram. If I were you I'd try out memtest86